Chlorogenic Acid( 3-O-Caffeoylquinic acid | Heriguard | NSC 407296 )

Catalog No. M14069 CAS No. 327-97-9

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Product Name

Chlorogenic Acid
Note

Research use only, not for human use.
Brief Description

Chlorogenic acid(NSC-407296; 3-O-Caffeoylquinic acid) is one of the most abundant polyphenols in the human diet, has been reported to inhibit Y cell growth and a major anti-inflammatory constituent of lonicerae flos extract.
Description

Chlorogenic acid(NSC-407296; 3-O-Caffeoylquinic acid) is one of the most abundant polyphenols in the human diet, has been reported to inhibit Y cell growth and a major anti-inflammatory constituent of lonicerae flos extract.
In Vitro

——
In Vivo

Animal Model:Experimental reflux esophagitis (RE) in ratsDosage:10, 30, 100 mg/kg Administration:p.o.Result:Reduced esophageal lipid peroxidation (marker: MDA) and increased the reduced glutathione/oxidized glutathione ratio. Inhibited the increases in the serum level of TNF-α, and expressions of iNOS and COX-2 protein.Animal Model:LPS/GalN-challenged mice Dosage:10 mg/kg Administration:i.v.Result:Increased survival rates of LPS/GalN-intoxicated mice.Inhibited LPS/GalN-induced phosphorylation of NF-κB p65 or c-Jun, without affecting p-IRF3 levels in the liver lobules.
Synonyms

3-O-Caffeoylquinic acid | Heriguard | NSC 407296
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

327-97-9
Formula Weight

354.32
Molecular Formula

C16H18O9
Purity

>98% (HPLC)
Solubility

Ethanol: 71 mg/mL (200.38 mM); Water: 18 mg/mL (50.8 mM); DMSO: 71 mg/mL (200.38 mM)
SMILES

O=C([C@@]1(O)C[C@@H](OC(/C=C\C2=CC=C(O)C(O)=C2)=O)[C@H](O)[C@H](O)C1)O
Chemical Name

(1S,3R,4R,5R)-3-{[(2Z)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,4,5-trihydroxycyclohexanecarboxylic acid

1. Illing EA, et al. Otolaryngol Head Neck Surg. 2015 Aug;153(2):291-7.

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